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Dosage - Oral: Children: Allergic conditions: 0.25 mg/kg/day or 8 mg/m 2 /day in 2-3 divided doses or 2-6 years: 2 mg every 8-12 hours (not to exceed 12 mg/day) 7-14 years: 4 mg every 8-12 hours (not to exceed 16 mg/day) Migraine headaches: 4 mg 2-3 times/day Children /= 12 years and Adults: Spasticity associated with spinal cord damage: 4 mg at bedtime; increase by a 4 mg dose every 3-4 days; average daily dose: 16 mg in divided doses; not to exceed 36 mg/day Children 13 years and Adults: Appetite stimulation (anorexia nervosa): 2 mg 4 times/day; may be increased gradually over a 3-week period to 8 mg 4 times/day Adults: Allergic conditions: 4-20 mg/day divided every 8 hours (not to exceed 0.5 mg/kg/day) Cluster headaches: 4 mg 4 times/day Migraine headaches: 4-8 mg 3 times/day Supplied Syrup, as hydrochloride: 2 mg/5 m L (473 m L) [contains alcohol 5%; mint flavor] Tablet, as hydrochloride: 4 mg Dosage - Oral: Children: 2-5 years: 12.5-25 mg every 6-8 hours, maximum: 75 mg/day 6-12 years: 25-50 mg every 6-8 hours, maximum: 150 mg/day Adults: 50-100 mg every 4-6 hours, not to exceed 400 mg/day Supplied Caplet (Trip Tone®): 50 mg Tablet (Dramamine®): 50 mg Tablet, chewable (Dramamine®): 50 mg [contains phenylalanine 1.5 mg/tablet and tartrazine; orange flavor] Mechanism of Action Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects.Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA).

Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).

A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.

Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).

Adults and children 12 years of age and older: take 1 tablet every 12 hours, not more than 2 tablets in 24 hours unless directed by a doctor.

Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.

Desloratadine inhibited histamine release from human mast cells in vitro.

In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.

Moreover, no sedative or other central nervous system effects were observed.

A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.

Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.

INDICATIONS AND USAGE: Karbinal ER (carbinoxamine maleate) Extended-release Oral Suspension is an H1 receptor antagonist indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis (1) Vasomotor rhinitis (1) Allergic conjunctivitis due to inhalant allergens and foods (1) Mild, uncomplicated allergic skin manifestations of urticaria and angioedema (1) Dermatographism (1) As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled (1) Amelioration of the severity of allergic reactions to blood or plasma (1) DOSAGE AND ADMINISTRATION The dosage of Karbinal ER should be individualized based on the severity of the condition and the response of the patient.

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